Adding Immune Therapies to ART: Can We Achieve a Functional Cure?
Joseph M. McCune, MD, PhD
Professor of Medicine in Residence
Chief, Division of Experimental Medicine
UCSF, San Francisco, CA
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At the completion of this educational session, learners will:
- Appreciate the limitations of antiretroviral therapy (ART).
- Know the mechanisms by which HIV may persist in the context of suppressive ART.
- Understand strategies by which persistence reservoirs of HIV may be reduced in size or eliminated.
Mike McCune is a Professor of Medicine and Chief of the Division of Experimental Medicine at University of California at San Francisco (UCSF). His past research has focused on the definition of pathogenic mechanisms of viral diseases, particularly HIV disease, and his current activities embrace and are motivated by the experiences of 30 years of work in the HIV epidemic. In the Division of Experimental Medicine, he has created a multidisciplinary, collaborative environment for the analysis of the human immunology of chronic infectious diseases. With his colleagues, Drs. Steve Deeks and Rafick Sekaly, he is leading a worldwide consortium of scientists that is addressing a number of hypotheses about how eradication might be achieved. This work is enabled by a bridging network of basic research labs and venues for clinical investigation, many of which Dr. McCune helped to build. He believes that this effort will eventually lead not only to the eradication (“cure”) of HIV within those who are infected, but also to the development of vaccines to prevent infection of those who are not.
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